Lying on the left bank of the River Ofanto, Lioni seems set at the foot of striking, proud mountains, against the backdrop of Monte Calvello and Monte Rematico. It was once an important junction on the Avellino–Rocchetta Sant'Antonio railway, which led to towns on the Adriatic and Tyrrhenian coasts. Of very ancient origin (Oppido may have been the first settlement), it was recorded in the 17th century as a hamlet that later became a busy commercial transit centre, and was razed to the ground by the 1980 earthquake. The Church of Santa Maria Assunta and the Sanctuary of San Rocco are the places of worship dearest to the townspeople. The small Church of the Annunziata dates from the 16th century, while a few remains survive of the Oppido fortress.

Following the course of the Ofanto, you come to the new Conza della Campania on the plain, entirely rebuilt after the 1980 earthquake, while on a fine hill above lies what remains of ancient Compsa. Here you can visit the Archaeological Park, with the Roman forum, the former Cathedral and the ruins left by the 1980 earthquake: living evidence of the town's antiquity, dating back to the time of the Hannibalic wars, and of its importance as the first diocese of the whole area.

A few kilometres away as the crow flies, and clearly visible thanks to its sedimentary rock profile resembling a whale, is Cairano, a tiny village whose origins go back to the Neolithic. Since 2007, thanks to the work of the association Irpinia 7x (chaired by Dario Bavaro), it has become a lively cultural centre, with its historic centre, open-air theatre, Via delle Cantine and Wind Organ. The route ends at Sant'Andrea di Conza, with its historic centre, the former Episcopio, the open-air theatre, the old mills, the former brickworks and the former Seminary.